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36 In this study, we also investigated the markers of inflammatory indicators and found that the expression of proinflammatory cytokine genes ( TNF-α , IL-6 , IL-1β and IL-23 ) and proteins (TNF-α and NF-κB) was notably upregulated in the intestine after 1.2 ~ 5 mg/kg of S-amlodipine treatment (Figure 4(a,b))